- Hypothyroidism: In the past, hypothyroidism was believed to produce an acquired form of von Willebrand disease in dogs. However, recent evidence indicates that hypothyroid dogs do not have consistently decreased vWf:Ag values and thyroid hormone supplementation actually lowers vWf:Ag values. However, hypothyroidism does appear to exacerbate the bleeding tendency in dogs with inherited von Willebrand disease. If an adult dog presents with a sudden onset of bleeding symptoms that are attributable to vWD, the dog should be evaluated for concurrent hypothyroidism. Hypothyroidism has also been associated with increased platelet counts in some animals.
- Hyperadrenocorticism: A hypercoagulopathy has been observed in animal patients with Cushing's disease, manifesting as thrombosis. In addition, corticosteroid therapy is a risk factor for the development of pulmonary thromboembolism. The exact mechanism for the increased incidence of thrombosis is as yet unknown.
|
